• Skip to primary navigation
  • Skip to main content
College of Agriculture & Life Sciences
Molecular Plant-Microbe Interaction Laboratory
  • Home
  • Research
    • Activation and Attenuation of Plant PRR Complexes and Signaling
    • Transcriptional, Post-transcriptional, and Post-translational Regulation of Plant Immunity
    • Coordination of Plant Immunity, Growth, and Development
    • Regulation of Plant Autoimmunity
    • Immunomodulatory Phytocytokines in Plant Immunity
    • Functional and Translational Genomics in Cotton Disease Resistance
    • Understanding and Improving Cotton Abiotic Stress Adaptation
  • People
    • Current
    • Alumni
  • Publications
  • Lab Activities
  • News and Awards
  • Education and Outreach
    • Outreach and Conferences
    • Research experience for undergraduate and high school students
  • Resources

Transcriptional, Posttranscriptional and Posttranslational Regulation of Plant Immunity

Plants have evolved two tiers of immune receptors to detect infections: cell surface-resident PRRs sensing microbial signatures and intracellular nucleotide-binding domain leucine-rich repeat (NLR) proteins recognizing pathogen effectors. We have developed sensitive genetic screens to identify Arabidopsis Genes Governing Immune gene Expression (AGGIEs) that regulate plant PRR- and/or NLR-mediated immunity. Genetic and biochemical analyses of AGGIEs have revealed the importance of gene transcriptional, posttranscriptional, translational, and posttranslational regulations in plant innate immunity. In particular, we have revealed an essential, but less characterized posttranslational modification protein ADP-ribosylation in plant immunity, and uncovered a molecular link between PRR and NLR protein complexes through cell surface-resident malectin-like domain receptor-like kinases.

Layered transcriptional, posttranscriptional, translational and posttranslational regulations in plant immunity. See Cell Reports (2019), 28:2194-2205.

Key references:

  1. Yu, X., Li, B., Jang, G. J., Jiang, S., Jang J.C. Wu, S. H.,Shan, L., and He, P.(2019) Orchestration of Processing body dynamics and mRNA decay in Arabidopsis immunity. Cell Reports 28: 2194-2205.
  2. Mang H., Feng, B., Hu, Z., Boisson-Dernier, A., Franck, C.M., Meng, X., Xu, G., Wang, T., Shan, L., and He, P. (2017)Differential regulation of two-tiered plant immunity and sexual reproduction by ANXUR receptor-like kinases. The Plant Cell.  29: 3140–3156.
  3. Feng, B., Liu, C., Oliveira, M.V.V., Intorne, A.C., Li, B., Babilonia, K., Filho, G.A.S., Shan, L., and He, P. (2015) Protein poly(ADP-ribosyl)ation regulates Arabidopsis immune gene expression and defense responses. PLoS Genetics11: e1004936.
  4. Li, F., Cheng, C., Cui, F., Oliveira, M.V.V., Yu, X., Meng, X., Intorne, A.C., Babilonia, K., Li, M., Chen, X., Ma, X., Xiao, S., Zeng, Y., Fei, Z., Metz, R., Johnson, C.D., Koiwa, H., Sun, W., Li, Z., Filho, G.A.S., Shan, L., and He, P. (2014) Modulation of RNA polymerase II phosphorylation downstream of pathogen perception orchestrates plant immunity. Cell Host & Microbe 16: 748-758.
Texas A&M University

© 2023 Texas A&M University. All rights reserved.

  • Compact with Texans
  • Privacy and Security
  • Accessibility Policy
  • State Link Policy
  • Statewide Search
  • Veterans Benefits
  • Military Families
  • Risk, Fraud & Misconduct Hotline
  • Texas Homeland Security
  • Texas Veterans Portal
  • Equal Opportunity
  • Open Records/Public Information